The lab’s work focuses broadly on identifying, and ultimately manipulating, novel pathways underlying T cell-driven inflammatory diseases. We are especially interested in interrogating novel mechanisms by which xenobiotic-sensing nuclear receptors and transporters mediate crosstalk between T cells and bile acids in the small intestine.
SELECTED PUBLICATIONS
Sudo, K. et al. Quantifying forms and functions of intestinal bile acid pools in mice. Cell Mol Gastroenterol Hepatol 18, 101392 (2024). doi: 10.1016/j.jcmgh.2024.101392
Chen, M. L. et al. CAR directs T cell adaptation to bile acids in the small intestine. Nature 593, 147–151 (2021). doi: 10.1038/s41586-021-03421-6
Chen, M. L. et al. Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes. J Exp Med 217, e20201434 (2020). doi: 10.1084/jem.20191388
Cao, W. et al. The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids. Immunity 47, 1182–1196.e10 (2017). doi: 10.1016/j.immuni.2017.11.012
Join Us
We are always looking for talented scientists. Please contact us for more information.
We accept graduate students through Dartmouth College’s Molecular and Cellular Biology (MCB) Ph.D. program. Please refer to the program’s page for more information.
SUNDRUD LAB 